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Showing 1 to 12 of 362 entries
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Correction to "assessing the dual activity of a chalcone-phthalocyanine conjugate: design, synthesis, and antivascular and photodynamic properties".

Molecular pharmaceutics

Tuncel S, Trivella A, Atilla D, Bennis K, Savoie H, Albrieux F, Delort L, Billard H, Dubois V, Ahsen V, Caldefie-Chézet F, Richard C, Boyle RW, Ducki S, Dumoulin F.
PMID: 25590168
Mol Pharm. 2015 Feb 02;12(2):663. doi: 10.1021/mp5008426. Epub 2015 Jan 15.

No abstract available.

Theranostic nanomedicine with functional nanoarchitecture.

Molecular pharmaceutics

Pan D.
PMID: 23452025
Mol Pharm. 2013 Mar 04;10(3):781-2. doi: 10.1021/mp400044j.

No abstract available.

Correction to "Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers".

Molecular pharmaceutics

Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB.
PMID: 29470076
Mol Pharm. 2018 Mar 05;15(3):1377. doi: 10.1021/acs.molpharmaceut.8b00130. Epub 2018 Feb 22.

No abstract available.

Correction for Spray Dried Aerosol Particles of Pyrazinoic Acid Salts for Tuberculosis Therapy.

Molecular pharmaceutics

Durham PG, Zhang Y, German N, Mortensen N, Dhillon J, Mitchison DA, Fourie PB, Hickey AJ.
PMID: 26394135
Mol Pharm. 2015 Oct 05;12(10):3782. doi: 10.1021/acs.molpharmaceut.5b00673. Epub 2015 Sep 22.

No abstract available.

A DNA Vaccine Delivery Platform Based on Elastin-Like Recombinamer Nanosystems for Rift Valley Fever Virus.

Molecular pharmaceutics

Gonzalez-Valdivieso J, Borrego B, Girotti A, Moreno S, Brun A, Bermejo-Martin JF, Arias FJ.
PMID: 32233501
Mol Pharm. 2020 May 04;17(5):1608-1620. doi: 10.1021/acs.molpharmaceut.0c00054. Epub 2020 Apr 10.

This work analyzes the immunogenicity of six genetically engineered constructs based on elastin-like recombinamers (ELRs) fused to the Gn glycoprotein from Rift Valley fever virus (RVFV). Upon transfection, all constructs showed no effect on cell viability. While fusion constructs...

Tumor-Associated Fibroblast-Targeting Nanoparticles for Enhancing Solid Tumor Therapy: Progress and Challenges.

Molecular pharmaceutics

Li W, Little N, Park J, Foster CA, Chen J, Lu J.
PMID: 34260250
Mol Pharm. 2021 Aug 02;18(8):2889-2905. doi: 10.1021/acs.molpharmaceut.1c00455. Epub 2021 Jul 14.

Even though nanoparticle drug delivery systems (nanoDDSs) have improved antitumor efficacy by delivering more drugs to tumor sites compared to free and unencapsulated therapeutics, achieving satisfactory distribution and penetration of nanoDDSs inside solid tumors, especially in stromal fibrous tumors,...

Improved Photodynamic Activity of Phthalocyanine by Adjusting the Chirality of Modified Amino Acids.

Molecular pharmaceutics

Mu X, Wang D, Lu S, Zhou L, Wei S.
PMID: 34927440
Mol Pharm. 2022 Jan 03;19(1):115-123. doi: 10.1021/acs.molpharmaceut.1c00672. Epub 2021 Dec 18.

Herein, four zinc phthalocyanines (ZnPcs) with chiral lysine modification were synthesized. We found that the chirality of lysine and the chiral structure position strongly influence the properties of ZnPcs. Among the four ZnPcs, d-lysine-modified ZnPc through -NH

Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transport Analysis.

Molecular pharmaceutics

Salehi N, Kuminek G, Al-Gousous J, Sperry DC, Greenwood DE, Waltz NM, Amidon GL, Ziff RM, Amidon GE.
PMID: 34428047
Mol Pharm. 2021 Sep 06;18(9):3326-3341. doi: 10.1021/acs.molpharmaceut.1c00262. Epub 2021 Aug 24.

Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane.

Increasing Drug Loading of Weakly Acidic Telmisartan in Amorphous Solid Dispersions through pH Modification during Hot-Melt Extrusion.

Molecular pharmaceutics

Thompson SA, Davis DA, Moon C, Williams RO.
PMID: 34846902
Mol Pharm. 2021 Nov 30; doi: 10.1021/acs.molpharmaceut.1c00805. Epub 2021 Nov 30.

Oral drug therapy requiring large quantities of active pharmaceutical ingredients (APIs) can cause a substantial pill burden, which can increase nonadherence and worsen healthcare outcomes. Maximizing the drug loading of APIs in oral dosage forms is essential to reduce...

Synchronizing .

Molecular pharmaceutics

Abd-Algaleel SA, Metwally AA, Abdel-Bar HM, Kassem DH, Hathout RM.
PMID: 34460250
Mol Pharm. 2021 Oct 04;18(10):3763-3776. doi: 10.1021/acs.molpharmaceut.1c00276. Epub 2021 Aug 30.

Sesamol is a sesame seed constituent with reported activity against many types of cancer. In this work, two types of nanocarriers, solid lipid nanoparticles (SLNs) and polymeric nanoparticles (PNs), were exploited to improve sesamol efficiency against the glioma cancer...

Transition from Amorphous Cyclosporin A Nanoparticles to Size-Reduced Stable Nanocrystals in a Poloxamer 407 Solution.

Molecular pharmaceutics

Chen Z, Higashi K, Ueda K, Moribe K.
PMID: 34843257
Mol Pharm. 2021 Nov 29; doi: 10.1021/acs.molpharmaceut.1c00721. Epub 2021 Nov 29.

Amorphous drug nanoparticles usually exhibit low storage stability. A comprehensive understanding of the molecular states and physicochemical properties of the product is indispensable for designing stable formulations. In the present study, an amorphous cyclosporin A (CyA) nanosuspension with a...

Effect of 'pH' on the Rate of Pyroglutamate Formation in Solution and Lyophilized Solids.

Molecular pharmaceutics

Bersin LM, Patel SM, Topp EM.
PMID: 34232660
Mol Pharm. 2021 Aug 02;18(8):3116-3124. doi: 10.1021/acs.molpharmaceut.1c00338. Epub 2021 Jul 07.

N-terminal glutamate can cyclize to form pyroglutamate (pGlu) in pharmaceutically relevant peptides and proteins. The reaction occurs nonenzymatically during storage for monoclonal antibodies and shows a strong 'pH' dependence in solution, but the solid-state reaction has not been studied...

Showing 1 to 12 of 362 entries